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Magnetic resonance imaging is a noninvasive diagnostic tool that allows a radiologist to visualize the inner body from the outside. MRI thus has broad potential for therapeutic and developmental applications. Magnetic resonance has been increasingly used for heart disease, brain injury and movement disorders. The challenge is to make the technology portable and suitable for widespread diagnostic use. The team of Chen et al. developed a portable MRI scanner that can measure the blood flow inside a patient’s body without the need for a magnet.
To generate a magnetic field to image blood flow, the researchers used conventional magnetic resonance techniques to induce voltages in oxygenated blood, which is less conductive than the deoxygenated blood in the vessels, and created an image from the electrical activity that then could be overlaid on the anatomical image. Human MRI scanners have been in existence for about 30 years, but were too large to be portable.
“That’s why most of the people that have cardiac problems were on the waiting list for heart transplants,” said team member Xin Chen, an assistant professor of biomedical engineering at Johns Hopkins, speaking on the plasma flow MRI project at the meeting.
The portable MRI is similar in some ways to a pair of defibrillators that are used to help halt a rapid heartbeat, but the system Chen and his colleagues designed is “a portable MRI system” that uses electrical pulses to provoke motions in the blood flow of the heart, which can be captured and displayed as an image on a computer screen.
The researchers programmed the computer to make many tests, all of which produced the same result, showing where the blood is flowing through the heart. The researchers think that the new MRI can also measure blood flow and blood oxygenation in other parts of the body, including the brain, muscles, and arteries. The group also plans to work with other medical imaging technologies, such as ultrasound, to combine with the MRI systems.
“Any imaging that we can do while the patient is mobile, we can potentially benefit from,” Chen said. “For example, with ultrasound we could do an ultrasound to look at the baby’s growth and with this MRI we can also measure how fast the blood flows in the baby’s brain.”
Researchers are just beginning to understand the medical and developmental applications of MRI. Although the technology has become generally accepted for clinical use, many researchers are hoping to determine how and