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Greater than 90% of the HIV-1 protease variants are resistant to the drug currently employed for therapy. However, inorganic nanoparticles have proven to be a promising effective means to overcome these limitations. A number of inorganic nanoparticles and surfaces have been proposed for the development of a delivery strategy of small-molecule anti-HIV-1 protease inhibitors. In particular, the selection of suitable inorganic nanoparticles has emerged as a fundamental aspect of the encapsulation of protease inhibitors for designing an efficient drug delivery carrier [ 4 ]. Protease inhibitors have been encapsulated in inorganic nanoparticles such as Ag, Au, ZnO, silicon, Al, Fe, and TiO 2. Simultaneously, inorganic nanomaterials have been explored to construct multifunctional hybrid nanoparticles such as surface-charge-selective Au nanoparticles ( 3 ) and inert ionic alumina oxide nanomaterials (4 ) both of which have been successfully used for the detection of surface proteins. Recently, inorganic nanoparticles, which possess high aqueous solubility, have been explored for targeted delivery of protease inhibitors. For instance, Ag-containing nanoparticles have been prepared for targeted delivery of ATV to CCR5+ 5. Similarly, covalently linked on a solid surface, SiO nanoparticles have been proposed as a promising drug-delivery vehicle. SiO nanoparticles have been used for targeted delivery of protease inhibitors such as ATV, darunavir (DRV) and etravirine (ETR) to 6. In addition, using zirconia (ZrO 7 ), a component of dental implant, is potentially beneficial for a combination therapy against AIDS.

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